A pre-structured helix in the intrinsically disordered 4EBP1
نویسندگان
چکیده
منابع مشابه
A pre-structured helix in the intrinsically disordered 4EBP1.
The eIF4E-binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.
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ژورنال
عنوان ژورنال: Molecular BioSystems
سال: 2015
ISSN: 1742-206X,1742-2051
DOI: 10.1039/c4mb00532e